If co-administration of Colchicine pills and also a P-gp prevention is essential, the dosage of Colchicine pills need to be readjusted by either decreasing the day-to-day dose or minimizing the dose regularity, as well as the individual should be monitored meticulously for Colchicine poisoning [View Clinical Pharmacology (12)]
Some medicines such as HMG-CoA reductase inhibitors and fibrates could raise the risk of myopathy when integrated with Colchicine capsules. Grievances of muscular tissue pain or weakness can be an indicator to inspect serum creatinine kinase degrees for indicators of myopathy.
Four pharmacokinetic studies evaluated the results of co-administration of voriconazole (200 mg BID), fluconazole (200 milligrams QD), cimetidine (800 mg BID), as well as propafenone (225 mg BID) on systemic degrees of Colchicine. Colchicine could be administered with these medications at the checked dosages without a demand for dose change. These results must not be theorized to other co-administered medicines [ View Drug-Drug Interactions (7.1, 7.2) and also Pharmacokinetics (12.
Pregnancy Category C. There are no appropriate and well-controlled studies with Colchicine capsules in expectant ladies. Colchicine crosses the human placenta. Developing researches in pets were not conducted with Colchicine capsules, nevertheless released pet duplication and also development research studies with Colchicine showed embryofetal poisoning, teratogenicity, and also altered postnatal advancement at direct exposures within or above the professional therapeutic variety. If the potential advantage justifies the prospective danger to the unborn child, Colchicine should be used throughout pregnancy just.
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